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The Entourage Effect: Cannabis Compounds Working Together

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Cannabis is a complex plant containing a wealth of compounds, including cannabinoids and terpenoids, which all interact with the mind and body. While the cannabinoids CBD and THC are often highlighted and championed, they are star players of a much larger team.

There are over 100 accompanying minor cannabinoids. There are also a wide range of terpenes, the aromatic oils found in spices, trees, and fruit, that provide unique smells and flavors to cannabis.

All of these compounds have their own unique and specific biochemical effect on the body. Combining these compounds provides a different physical or psychological impact than a single compound on it's own - this is what is known as the 'entourage effect'.

What is the Entourage Effect?

Famed cannabis researcher Dr. Raphael Mechoulam was the first to use the term in reference to cannabis in an article published in 1998. It wasn't until 2011 however that the phrase was popularized thanks to a paper by Dr. Ethan Russo entitled Taming THC: Potential Cannabis Synergy and Phytocannabinoid-Terpenoid Entourage Effects.

These papers showed that cannabis compounds consumed in tandem display synergistic interactions with one another. For example, a 2008 study by Dr. Russo concluded that secondary compounds including CBD may enhance the beneficial effects of THC and prevent unwelcome side effects.

The combined consumption of varied cannabinoids and terpenes holds huge potential. The goal of researchers is to find chemical combinations that work in chorus with each other to synergistically increase the overall outcome when compared to consuming single, isolated compounds.

CBD Along the Spectrum

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Similar to eating whole fruits and veggies, consuming as close to a 'whole-plant' spectrum of these cannabis compounds is generally regarded as best practice. The idea is that by consuming a diverse variety of compounds, you'll find superior therapeutic outcomes.

In the early days of the hemp-CBD industry, the isolated CBD molecule quickly grew to popularity because it is inexpensive to produce, versatile, and free of THC. The downside however is that CBD isolate has no other supporting compounds. The isolation of this compound has been helpful in producing pharmaceutical-minded formulations but leaves the general user wanting.

On the other hand, full-spectrum products deliver a dose of the full range of hemp-sourced compounds. The performance of full-spectrum products has been observed to offer a broader therapeutic window and to work well at much lower doses. This is why here at Big Sky Botanicals we don't carry any CBD isolate-based products and only provide full and broad-spectrum products.

For more information on spectrums, see our article on the topic.

An Exciting Future Lies Ahead

The future of the entourage effect is one of the most exciting horizons for cannabis. Additional research will enable specific formulations containing specific compounds to be created to address specific ailments.

For example, research shows that a common terpene called limonene helps increase the absorption of other terpenes and cannabinoids through the skin, mucous membranes, and digestive tract. Additionally, the interaction between cannabinoids THC and CBN resulted in enhanced sedating effects when compared to either compound consumed in isolation.

Specific chemical formulations have long been at play in the smoked cannabis industry. Strains containing tailored combinations of cannabinoids and terpenes are sold to provide unique therapeutic outcomes. While a cornerstone of smoked cannabis, strains are "limited" by their natural composition, and suffer from inconsistencies in their chemical makeup.

The extraction facility and laboratory are emerging as the new frontier of cannabis. Extracted cannabis offers the opportunity for crafting accurate, repeatable cannabinoid, and terpene profiles. As research continues, specific formulations for specific needs are sure to emerge and rise to popularity.

Already today we are seeing formulations like 1:1 CBD to CBG, CBN, or THC. While the future is bright in these areas, the tried and true whole-plant approach still dominates the market as it's often best to let nature provide the medicines it designed.




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